Hepatic CYP Isoforms and Drug-Metabolizing Enzyme Activities in Broiler Chicks
نویسندگان
چکیده
منابع مشابه
Hormonal regulation of hepatic drug-metabolizing enzyme activity during adolescence.
Activities of drug-metabolizing enzymes (DMEs) are known to change throughout the course of physical and sexual maturation, with the greatest variability noted during infancy and adolescence. The mechanisms responsible for developmental regulation of DME are currently unknown. However, the hormonal changes associated with puberty/adolescence provide a theoretical framework for understanding the...
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Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b s and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsom...
متن کاملInterlobular distribution of hepatic xenobiotic-metabolizing enzyme activities in cattle, goats and sheep.
Microsomal and cytosolic enzymes that metabolize xenobiotics were measured in composite samples representing entire livers and in samples from three lobes, using livers of cattle, goats and sheep. Within individual species, concentrations of cytochrome P-450 and b5 and activities of NADPH cytochrome c reductase, aldrin epoxidase, aminopyrine N-demethylase, ethoxycoumarin O-deethylase, microsoma...
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‰Á " ¡ —²ˆê Kato et al. (1-3) and Booth and Gillette (4) demonstrated that the sex difference in the activities of drug-metabolizing enzyme systems of rat liver microsomes is related to the anabolic action of male sex hormone. In fact, they demonstrated increases in the activities of drug-metabolizing enzymes of liver microsomes of castrated female rats by the treatment with synthetic hormones ...
متن کاملGreat Britain Hepatic Drug - Metabolizing Enzyme Activity in Rats Pretreated with ( - ) - Emetine or ( ± ) - 2 , 3 - Dehydroemetine
1. Pretreatment of female rats with (-)-emetine or (±)-2,3-dehydroemetine (at 18,umol/kg body wt. for 24h) prolongs the hexobarbital-induced sleeping-time of the treated animals. 2. This effect is not observed on pretreating animals with other compounds closely related to (-)-emetine, such as (-)-isoemetine or (+)-O-methylpsychotrine. 3. Liver microsomal drug-metabolizing enzyme activity in vit...
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ژورنال
عنوان ژورنال: International Journal of Poultry Science
سال: 2006
ISSN: 1682-8356
DOI: 10.3923/ijps.2006.104.111